Gene K. Beare Distinguished Professor in Biomedical Engineering, McKelvey School of Engineering, Washington University in St. Louis
Professor of Biomedical Engineering, Washington University in St. Louis
Director, Center for Biomolecular Condensates (CBC), Washington University in St. Louis
Member of the Hope Center for Neurological Disorders, Washington University School of Medicine
Contact: pappu@wustl.edu
Phone: (314) 935-7958
Office: Brauer Hall, Room 2015a
| July 2022 - current | Director, Center for Biomolecular Condensates (CBC), James McKelvey School of Engineering, Washington University in St. Louis | |||
| September 2021 - current | Gene K. Beare Distinguished Professor in Biomedical Engineering, McKelvey School of Engineering, Washington University in St. Louis | |||
| January 2018 - June 2022 | Director, Center for Science & Engineering of Living Systems (CSELS), James McKelvey School of Engineering, Washington University in St. Louis, Washington University in St. Louis | |||
| March 2015 - August 2021 | Edwin H. Murty Professor of Engineering, McKelvey School of Engineering, Washington University in St. Louis | |||
| September 2012 - December 2018 | Director, Center for Biological Systems Engineering, Washington University in St. Louis, School of Engineering & Applied Sciences | |||
| January 2013 - January 2018 | Co-Director, Center for High Performance Computing, Washington University in St. Louis | |||
| January 2011 - current | Professor, Department of Biomedical Engineering, Washington University in St. Louis, School of Engineering & Applied Sciences | |||
| March 2007 - current | Member, Hope Center for Neurodegenerative Disorders, Washington University School of Medicine | |||
| July 2007 - December 2010 | Associate Professor, Department of Biomedical Engineering, Washington University in St. Louis, School of Engineering & Applied Sciences; Adjunct Associate Professor, Department of Biochemistry & Molecular Biophysics, Washington University School of Medicine | |||
| February 2009 - August 2010 | Director, Center for Computational Biology, Washington University School of Medicine | |||
| May 2002 - August 2010 | Member, Center for Computational Biology, Washington University School of Medicine | |||
| September 2001 - June 2007 | Assistant Professor, Department of Biomedical Engineering, Washington University in St. Louis | |||
1998 - 2001: Postdoctoral Training, Johns Hopkins University School of Medicine
1996 - 1998: Postdoctoral Training, Washington University School of Medicine
1996: Ph.D. Biological Physics, Tufts University, John F. Burlingame Graduate Fellowship
1989: B.Sc. Physics, Electronics, Mathematics, St. Joseph's College, Bangalore India, National Merit Scholarship
July 2022 - current: Director, Center for Biomolecular Condensates (CBC), James McKelvey School of Engineering, Washington University in St. Louis
September 2021 – current: Gene K. Beare Distinguished Professor of Engineering, McKelvey School of Engineering, Washington University in St. Louis
July 2018 - June 2022: Director, Center for Science & Engineering of Living Systems (CSELS), James McKelvey School of Engineering, Washington University in St. Louis
March 2015 – current: Edwin H. Murty Professor of Engineering, Washington University in St. Louis, School of Engineering & Applied Sciences
September 2012 – December 2018: Director, Center for Biological Systems Engineering, Washington University in St. Louis, School of Engineering & Applied Sciences
January 2013 – January 2018: Co-Director, Center for High Performance Computing, Washington University in St. Louis
January 2011 – current: Professor, Department of Biomedical Engineering, Washington University in St. Louis, School of Engineering & Applied Sciences
March 2007 – current: Member, Hope Center for Neurodegenerative Disorders, Washington University School of Medicine
July 2007 – December 2010: Associate Professor, Department of Biomedical Engineering, Washington University in St. Louis, School of Engineering & Applied Sciences; Adjunct Associate Professor, Department of Biochemistry & Molecular Biophysics, Washington University School of Medicine
February 2009 – August 2010: Director, Center for Computational Biology, Washington University School of Medicine
May 2002 – August 2010: Member, Center for Computational Biology, Washington University School of Medicine
September 2001 – June 2007: Assistant Professor, Department of Biomedical Engineering, Washington University in St. Louis
Contact: kiersten.ruff@wustl.edu
Ph.D. in Computational and Systems Biology, Washington University in St. Louis (2017)
Research:
Uncovering functional molecular grammars of IDRs using alignment-free computations; Advanced machine-learning methods for modeling IDPs, linkage processes in phase separation, and multiscale methods for simulating IDPs.
Contact: souradeep@wustl.edu
Ph.D. in Physics, Indian Institute of Science Education and Research (IISER), Kolkata, India (2024)
Research:
Physics of complex coacervation and charge regulation as it relates to nucleolar organization; incorporating hydration and ion effects into descriptions of polyelectrolyte conformational, binding, and phase equilibria.
Contact: matthewking@wustl.edu
Ph.D. in Molecular Biology, Princeton University (2019)
Research:
Ruth L. Kirschstein NRSA (F32) Postdoctoral Fellow working on biochemical reconstitutions of functional and structural facsimiles of nucleoli; Uncovering the functional implications of molecular grammars of IDRs and working in collaboration with the Kadoch Lab.
Contact: mshinn@wustl.edu
Ph.D. in Physics (BioPhysics), Washington University in St. Louis (2020).
Research:
Physics of microphase separation of RRM containing proteins; reconstitutions of nuclear speckle territories; And the development of novel methods for quantifying mechanisms of biomolecular condensation.
Contact: dylant@wustl.edu
Ph.D. in Biological Chemistry, University of Pittsburgh (2023).
Research:
Effects of charge regulation on the charge states of IDPs and the driving forces condensation in protein-RNA mixtures; Structural studies based on cryo EM methods for characterizing biomolecular condensates.
Contact: ruoyaoz@wustl.edu
Ph.D. in Mechanical and Aerospace Engineering and Materials Science, Princeton University (2024).
Research:
Multiscale computations of interphase and interfacial properties of condensates; impact of percolation on clusters in sub-saturated solutions and internal organization and material properties of condensates; Modeling phase behaviors of multicomponent systems.
Contact: liu.vicky@wustl.edu
Ph.D. Student in Biomedical Engineering
BS Physics (dual-major in Physics and Quantitative Sciences), Emory University (2022)
Research:
Co-evolution of IDRs and folded domains; Multiscale modeling of intrinsic and RNA-mediated microphase separation of RRM containing proteins; Simulations of the effects of charge regulation on conformational ensembles of IDPs.
Contact: a.pant@wustl.edu
Ph.D. Student, Yoram Rudy Graduate Fellow, in Biomedical Engineering
M.Tech in Polymers and Biosystems Engineering, Indian Institute of Technology Hyderabad (2022)
B.Tech in Biotechnology, Amity University (2020)
Research:
Investigating the effects of nucleolar pH gradients on biochemical activities and macromolecular fluxes; Interphase and interfacial potentials of nuclear bodies and their functional consequences in vitro and in live cells.
If you are interested in rotating within the lab, please contact Rohit Pappu (pappu@wustl.edu) for more details.
Ph.D. student in Biochemistry Biophysics and Structural Biology
September 2022 - April 2024
Ph.D. in Physics
July 2022
Ph.D. in Plant & Microbial Biosciences
September 2023
Ph.D. in Biomedical Engineering
May 2023
Ph.D. in Physics
September 2021
Ph.D. in Biomedical Engineering
December 2020
Ph.D. in Physics
April 2017
Ph.D. in BioPhysics
May 2017
Ph.D. in Computational and Systems Biology
May 2013
Ph.D. in Computational and Molecular Biophysics
August 2012
Ph.D. in Biomedical Engineering
June 2011
B.S. / M.S. in Biomedical Engineering
May 2011
Ph.D. in Biomedical Engineering
December 2009
M.S. in Molecular Biophysics
May 2009
Ph.D. in Molecular Biophysics
June 2009
Ph.D. in Molecular Biophysics
April 2009
Ph.D. in Biomedical Engineering
December 2007
Lab Member: March 2017 - December 2023
Lab Member: July 2014 - August 2023
Lab Member: August 2018 - August 2019
Lab Member: August 2017 - June 2018
Lab Member: August 2013 - May 2014
Lab Member: December 2009 - September 2015
Lab Member: September 2021 - July 2024
Lab Member: February 2022 - May 2024
Lab Member: March 2018 - December 2022
Lab Member: September 2020 - June 2021
Lab Member: January 2015 - December 2020
Lab Member: May 2017 - December 2019
Lab Member: August 2016 - April 2019
Lab Member: Oct 2016 - Nov 2017
Lab Member: Oct 2015 - June 2016
Lab Member: February 2012 - October 2014
Lab Member: April 2012 - May 2013
Lab Member: November 2010 - August 2011
Lab Member: June 2006 - December 2009
Lab Member: September 2004 - February 2008
Lab Member: September 2002 - June 2004
Lab Member: August 2009 - December 2010
Lab Member: August 2018 - October 2022
Visting graduate student from the Institute of Advanced Chemistry of Catalonia of the Spanish Council for Scientific Research (IQAC-CSIC), Barcelona, Spain
Fall 2016
Summer 2021 - Spring 2022
Summer 2020 - Spring 2022
Summer 2019, Summer 2020
Summer 2018 - Spring 2020
Summer 2019 - Spring 2020
Summer 2017 - Summer 2018
Summer 2013, Spring/Summer 2015, Spring 2017
Fall 2016, Spring 2017
Summer 2015
Summer 2014
Summer 2012, Summer 2013 - Summer 2014
Summer 2012
Summer 2012
Spring 2012
Summer 2011 and 2012
Summer 2011
Summer 2011
Fall 2010 - Spring 2011
Spring 2011
Summer 2009 and 2010
Fall 2009 - Spring 2010
Summer 2009
Summer 2008
Summer 2007
Fall 2004 - Spring 2005
Fall 2004 - Spring 2005
