Pappu Lab

Pappu Lab

Welcome to the lab of Rohit Pappu in the Department of Biomedical Engineering at Washington University in St. Louis

Laboratory of Computational Biophysics and Molecular Engineering


Laboratory of Computational Biophysics and Molecular Engineering


The Pappu lab has openings for multiple postdoctoral positions. We are looking for highly motivated and hard working individuals with interests and expertise in the areas of statistical physics, computational biophysics, and polymer physics. The chosen candidates will work actively on the development and deployment of multiscale simulations that enable a first principles understanding of the conformations, interactions, and phase behavior of intrinsically disordered proteins. The positions are open to be filled right away.

Interested candidates should send their full CV and a list of at least three referees to Dr. Rohit Pappu.


Our research is focused on the study of intrinsically disordered proteins.

We develop and use state-of-the-art computational methods and combine these with experimental techniques to understand how information encoded in amino acid sequences of intrinsically disordered proteins governs their molecular function, contributes to organization of protein interaction networks, controls cellular decisions, and modulates the mechanisms of protein self-assembly.

We combine methods and theory development with simulations and experiment to construct a multiscale, multidimensional description of systems. By understanding the system as a whole we can re-design individual components using fundamental principles to further explore the functional limits defined by nature.


The Pappu lab has openings for multiple postdoctoral positions. We are looking for highly motivated and hard working individuals with interests and expertise in the areas of statistical physics, computational biophysics, and polymer physics. The chosen candidates will work actively on the development and deployment of multiscale simulations that enable a first principles understanding of the conformations, interactions, and phase behavior of intrinsically disordered proteins. The positions are open to be filled right away.

Interested candidates should send their full CV and a list of at least three referees to Dr. Rohit Pappu.


Our research is focused on the study of intrinsically disordered proteins. We develop and use state-of-the-art computational methods and combine these with experimental techniques to understand how information encoded in amino acid sequences of intrinsically disordered proteins governs their molecular function, contributes to organization of protein interaction networks, controls cellular decisions, and modulates the mechanisms of protein self-assembly.


Relevant diseases: Huntington's disease; Alzheimer's disease; Prion diseases; Cancers

Proteins or protein classes of interest: Huntingtin; Polyglutamine containing proteins; Tau; Amyloid Beta; BHLH and BZIP Transcription Factors; Scaffolding Proteins; Nuclear Proteomes; Low complexity sequences

Processes of Interest: Self-Assembly via homotypic interactions; Phase Transitions of multi-macromolecular systems; Functions via entropic machines; Proteostasis; Nuclear Transport; Prion-like propagation of aggregates

Techniques used: Atomistic and mesoscopic computer simulations; Polymer physics theories; Modeling hierarchical networks; Bioinformatics; In vitro biophysical experiments


Funding: We currently receive funding from the National Science Foundation (NSF), the National Institute for Neuronal Disorders and Stroke (NIH-NINDS), the National Institute of General Medical Sciences (NIH-NIGMS) and Washington University's Center for Biological Systems Engineering.


Last updated August 9th 2016